List of all products

available from Reaxense

Natural Fragment Library

Natural products have contributed to the development of many drugs for diverse indications and they continue to be an important source of leads for new medicines, despite reduced interest from large pharmaceutical companies. The development of new technologies including fragment-based drug discovery (FBDD) has revolutionized the screening of natural products as potential therapeutic agents.

Ro3 Fragment Library

In the past decade, fragment based drug design (FBDD) has risen as a new and effective approach to identify lead compounds and continues to show great promise in drug discovery. It requires the use of sensitive techniques such as X-ray crystallography to identify hits among low molecular weight fragment compounds that have a weak binding affinity to a drug target. The hit fragments could be then structurally optimized to lead compounds with high affinity and specificity.

RNA Targeted Focused Library

For the last several decades, progress in RNA investigations revealed earlier underestimated importance of RNA in normal and abnormal cellular processes. It is now clear that regulation of translation and transcription, protein and enzyme functions that have commonly been attributed to proteins are frequently in RNAs' competency.

The multitude of recent research articles devoted to the wide variety of diseases, including viral and bacterial infections, cancer and degenerative processes, emphasized the high potential of approaches targeted on the structure of particular RNA.

Alikeness PPI Focused Library

Majority of biological processes would not be possible without protein–protein interactions (PPIs). Human interactome is estimated to comprise more than 600,000 PPIs, and only a small part of them has been studied. PPIs are associated with a growing number of diseases and have garnered significant interest in pharmaceutical research offering attractive opportunities for therapeutic intervention. Designing molecules that interfere with the formation of protein complexes is one of the recent challenges in drug design.

BET Bromodomains Focused Library

Bromodomains are acetyl-lysine recognition modules of a diverse group of proteins that play crucial role in chromatin organization and regulation of gene transcription. Proteins that contain bromodomains have been involved in the development of a large variety of diseases. Bromodomain and extra-terminal (BET) proteins, which belong to a class of proteins collectively called epigenetic “readers”, have recently emerged as prospective drug targets for treatment of cancers, inflammatory diseases, and other medical conditions.